From the Ted Talk by Anees Bahji: What is schizophrenia?
Unscramble the Blue Letters
The aoisntphtyicc drugs used to traet shprceiohizna have helped researchers work backwards to trace signatures of the disorder in the biran. Traditional antipsychotics block dopamine receptors. They can be very effective in reducing positive symptoms, which are linked to an ecxses of dopamine in particular brain pathways. But the same drugs can make negative symptoms worse, and we’ve found that negative smotmyps of schizophrenia may be tied to too little dopamine in other brain areas. Some people with schizophrenia show a loss of naerul tissue, and it’s unclear whether this atrophy is a result of the disease itself or drug-induced suppression of signaling. Fortunately, newer generations of antypiicoscths aim to address some of these issues by targeting mpltilue neurotransmitters, like sinrooetn in addition to dopamine. It’s clear that no one tntreismtar system is responsible for all symptoms, and because these drugs affect signaling throughout the brain and body, they can have other side effects like weight gain.
Open Cloze
The _____________ drugs used to __________________ have helped researchers work backwards to trace signatures of the disorder in the _____. Traditional antipsychotics block dopamine receptors. They can be very effective in reducing positive symptoms, which are linked to an ______ of dopamine in particular brain pathways. But the same drugs can make negative symptoms worse, and we’ve found that negative ________ of schizophrenia may be tied to too little dopamine in other brain areas. Some people with schizophrenia show a loss of ______ tissue, and it’s unclear whether this atrophy is a result of the disease itself or drug-induced suppression of signaling. Fortunately, newer generations of ______________ aim to address some of these issues by targeting ________ neurotransmitters, like _________ in addition to dopamine. It’s clear that no one ___________ system is responsible for all symptoms, and because these drugs affect signaling throughout the brain and body, they can have other side effects like weight gain.
Solution
antipsychotics
transmitter
symptoms
neural
serotonin
brain
antipsychotic
schizophrenia
treat
multiple
excess
Original Text
The antipsychotic drugs used to treat schizophrenia have helped researchers work backwards to trace signatures of the disorder in the brain. Traditional antipsychotics block dopamine receptors. They can be very effective in reducing positive symptoms, which are linked to an excess of dopamine in particular brain pathways. But the same drugs can make negative symptoms worse, and we’ve found that negative symptoms of schizophrenia may be tied to too little dopamine in other brain areas. Some people with schizophrenia show a loss of neural tissue, and it’s unclear whether this atrophy is a result of the disease itself or drug-induced suppression of signaling. Fortunately, newer generations of antipsychotics aim to address some of these issues by targeting multiple neurotransmitters, like serotonin in addition to dopamine. It’s clear that no one transmitter system is responsible for all symptoms, and because these drugs affect signaling throughout the brain and body, they can have other side effects like weight gain.